decrease pre-op (before surgery) discomfort by reducing anxiety, hunger, and thirst
11
Intra-Op dosing: To be administered if the duration of the procedure exceeds 2 half-lives of Feb 1, 2013 · This work represents an update to the previously published ASHP Therapeutic Guidelines on Antimicrobial Prophylaxis in Surgery, as well as guidelines from IDSA and SIS
Dose of antibiotics: Please see Table II for dosing and re-dosing guidelines
Antibiotic Ampicillin Ampicillin/sulbactam Cefazolin Clindamycin Gentamicin Vancomycin
Reviewed by Antibiotic Subcommittee: 2/2021 Approved by UCDH Pharmacy and
Adult: Metronidazole 500 mg IV + Gentamicin 1
strongly recommended that vancomycin be administered over a minimum of 60 minutes
Metronidazole One-time dose Pre-operative * * Duration dependent on surgical
Prophylactic antibiotics should be administered within 1 hour prior to incision
g
Prophylaxis not routinely indicated
001), a shorter hospital length of p Podda M, Cillara N, Di Saverio S, et al
Fixed-dose combinations were used, the most common being ceftriaxone and sulbactam
Administer within 60 minutes p rior to surgical incision
Sedatives may be given intravenously, in pill form, or inhaled through a mask
Single dose of i/v cefuroxime + i/v metronidazole or i/v gentamicin + i/v metronidazole or i/v co-amoxiclav alone (additional intra-operative or postoperative doses may be given for prolonged procedures or if there is major blood loss)
5 to 40 mg/kg/day IV in 3 or 4 divided doses
e
Metronidazole One-time dose Pre-operative * * Duration dependent on surgical findings: • If clean, no post op • If spillage found, consider 24 hours only **Consider 4-day course post source control of Piperacillin-tazobactam (Vancomycin + Aztreonam + Metronidazole if severe allergy) II
Data indicate that for lengthy procedures, administering additional intraoperative doses of an antibiotic can maintain adequate levels throughout the surgery
Cefepime plus metronidazole: Daskalakis K, Juhlin C, Pahlman L
Similarly, a 2012 retrospective study conducted by Cannon et al showed a 57% decrease in surgical site infection when oral antibiotics plus mechanical bowel preparation were used in elective colon resections ( n = 9,940)
Demographic data, including sex, age, weight, height, arterial blood pressure, clinical diagnosis, operative procedure (duration and type of